Anti-inflammatory (or antiinflammatory) is the property of a substance or treatment that reduces inflammation or swelling. Anti-inflammatory drugs make up about half of analgesics, remedying pain by reducing inflammation as opposed to opioids, which affect the central nervous system to block pain signaling to the brain.
In addition to medical drugs, some herbs and health supplements may have anti-inflammatory qualities: bromelain from pineapples (Ananas comosus).^[26] Cannabichromene, a cannabinoid, also has anti-inflammatory effect.^[27] Honokiol from Magnolia inhibits platelet aggregation, and works as an inverse agonist at the CB2 receptor. Black seed (Nigella sativa) has shown anti-inflammatory effect due to its high thymoquinone content.^[28] St. John's wort's chief constituent, hyperforin, has been found to be a potent COX-1 and 5-LO inhibitor, with anti-inflammatory effect several fold that of aspirin.^[29]

Coal tar has been used for centuries for its anti-inflammatory and analgesic effects. Oral administration for central effects is now rare as coal tar also contains a range of dangerous and carcinogenic compounds, and does not allow for the administration of standardized doses, although some doctors readily utilize coal tar preparations for topical administration (ex. Denorex, Psoriasin) in the treatment of skin conditions such as eczema and atopic dermatitis. Many modern analgesics and anti-inflammatory agents (ex. paracetamol, and its previously used predecessor phenacetin) are derived from compounds which were originally discovered during studies to elucidate the chemicals responsible for the tars reputed health benefits.^[30][31]

EGF
- EGF, Sh-oligopeptide -1 (Epidermal Growth Factor EGF)

INCI Name: sh-oligopeptide-5/sh-oligopeptide SP
Trade Name : TSC_EGF

EGF (Epidermal Growth Factor EGF)
https://en.wikipedia.org/wiki/Epidermal_growth_factor https://pubchem.ncbi.nlm.nih.gov/#query=EGF%09Sh%20oligopeptide https://en.wikipedia.org/wiki/SCYE1 https://en.wikipedia.org/wiki/List_of_human_protein-coding_genes_1?wprov=srpw1_6

EGF acts by binding with high affinity to epidermal growth factor receptor (EGFR) on the cell surface. This stimulates ligand-induced dimerization,^[12] activating the intrinsic protein-tyrosine kinase activity of the receptor (see the second diagram). The tyrosine kinase activity, in turn, initiates a signal transduction cascade that results in a variety of biochemical changes within the cell – a rise in intracellular calcium levels, increased glycolysis and protein synthesis, and increases in the expression of certain genes including the gene for EGFR – that ultimately lead to DNA synthesis and cell proliferation.^[13]

EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. Besides EGF itself other family members include:^[14]

·        Heparin-binding EGF-like growth factor (HB-EGF)

·        transforming growth factor-α (TGF-α)

·        Amphiregulin (AR)

·        Epiregulin (EPR)

·        Epigen

·        Betacellulin (BTC)

·        neuregulin-1 (NRG1)

·        neuregulin-2 (NRG2)

·        neuregulin-3 (NRG3)

·        neuregulin-4 (NRG4).

All family members contain one or more repeats of the conserved amino acid sequence:

CX₇CX_4-5CX_10-13CXCX₈GXRC

Where C is cysteine, G is glycine, R is arginine, snd X represents any amino acid.^[14]

This sequence contains six cysteine residues that form three intramolecular disulfide bonds. Disulfide bond formation generates three structural loops that are essential for high-affinity binding between members of the EGF-family and their cell-surface receptors.^[5]

Gene location (Human)

OGG1
- OGG1- 8-Oxoguanine glycosylase

INCI Name : Have being Applying
Trade Name : TSC_OGG1

Oxoguanine glycosylase
https://en.wikipedia.org/wiki/Oxoguanine_glycosylase

8-Oxoguanine glycosylase also known as OGG1 is a DNA glycosylase enzyme that, in humans, is encoded by the OGG1 gene. It is involved in base excision repair. It is found in bacterial, archaeal and eukaryotic species.